Ex Vivo Imaging
Whole Tissue 3D Imaging of Tissue Sample, Ex Vivo
IVIM Technology’s contract R&D service provides a high-quality whole tissue 3D imaging from the surface into deep tissue including cell distribution, structural changes.
Deep Tissue Imaging with Tissue Clearing Technique
Imaging of cell distribution, structural changes (vessel, lymphatic, capsule) in optically cleared tissues
- • Primary tumor, metastasized tissues, etc.
Lymph Node
Normal
Neutrophil
Vessel

Metastasis - Day 10

Metastasis - Day 13

Primary Tumor
Vessel
Breast cancer cell

- • Various tissues in chimeric model (Lymph node, kidney, etc.)
Lymph Node
B cell zone
T cell
B cell
Vessel

T cell zone

3D
T cell
B cell

- • Normal skin (hair follicle), tooth, lymph node, internal organs (liver, spleen, kidney), etc.
Skin
Basal cell
Actin
Nuclei

Sebaceous gland

Muscle & vessel

Tooth
Nonirritated
Vessel
Granulocyte
Autofluorescence

irritated

irritated

Validation of Drug Delivery & Action
Delivery of therapeutic candidates and cosmetics into deep tissues
- • Drug delivery to deep tissue (hair follicle, cortex, hippocampus, etc.)
- • Transdermal delivery of cosmetic complex
Skin
Normal
Fluorophore

Modified #1

Modified #2

Whole Tissue 3D Imaging with Tissue Clearing Technique
Imaging of cell distribution, structural changes (vessel, lymphatic, capsule) in optically cleared tissues
- • Imaging various tissue obtained from normal & disease model
- • Colormap by imaged depth