Ex Vivo Imaging

Whole Tissue 3D Imaging of Tissue Sample, Ex Vivo

IVIM Technology’s contract R&D service provides a high-quality whole tissue 3D imaging from the surface into deep tissue including cell distribution, structural changes.

Deep Tissue Imaging with Tissue Clearing Technique Imaging of cell distribution, structural changes (vessel, lymphatic, capsule) in optically cleared tissues

• Primary tumor, metastasized tissues, etc.

Lymph Node

Normal

Neutrophil

Vessel

Metastasis - Day 10

Metastasis - Day 13

Primary Tumor

Vessel

Breast cancer cell

• Various tissues in chimeric model (Lymph node, kidney, etc.)

Lymph Node

B cell zone

T cell

B cell

Vessel

T cell zone

T cell

B cell

• Normal skin (hair follicle), tooth, lymph node, internal organs (liver, spleen, kidney), etc.

Skin

Basal cell

Actin

Nuclei

Sebaceous gland

Muscle & vessel

Tooth

Nonirritated

Vessel

Granulocyte

Autofluorescence

irritated

Validation of Drug Delivery & Action Delivery of therapeutic candidates and cosmetics into deep tissues

• Drug delivery to deep tissue (hair follicle, cortex, hippocampus, etc.)
• Transdermal delivery of cosmetic complex

Skin

Normal

Fluorophore

Modified #1

Modified #2

Whole Tissue 3D Imaging with Tissue Clearing Technique Imaging of cell distribution, structural changes (vessel, lymphatic, capsule) in optically cleared tissues

• Imaging various tissue obtained from normal & disease model
• Colormap by imaged depth