In vivo Drug Delivery Monitoring
In Vivo Imaging of Drug Delivery & Clearance at Target Cells & Tissues
IVIM Technology’s contract R&D service provides a direct imaging analysis of delivery to target tissue and cells, efficacy, and mode of action (MOA) of new therapeutic candidates in microscopic cellular-level in various preclinical model of human disease.
Monitoring of Drug Delivery & Clearance in Target Tissues
Delivery and clearance of fluorescently labeled novel therapeutic candidates
- • Fluorescently labeled therapeutics : Antibody, protein, peptide, exosome, nanoparticle, cell, gene, plasmid, small molecules, etc.
- • Target tissue : Primary tumor tissue, surrounding microenvironment, major site of tumor metastasis (lymph node, liver, lung, brain, etc.)
- • Anti-tumor therapeutics : Cytotoxic drugs, anti-angiogenic drugs, etc.
Tumor
2 h
6 h
24 h
Tumor
2 h
6 h
24 h
Retinal delivery
- • Administration route : Eyedrops, intravenous injection, intravitreal injection, etc.
Retina
Day 2
Day 6
Day 13
Sustained drug release from drug complex
- • Drug complex types : Skin patch, transplantable complex, etc.
BBB penetration & delivery to brain tissue
- • Target disease : Neurodegenerative disease, Stroke, etc.
Brain, Cortex
Control
Drug
Drug
Brain, Cortex
Control
Drug
Drug
Cellular Uptake of Therapeutic Candidates
Cellular uptake of new therapeutic candidates by target cells
- • Tissue cells : Vascular endothelial cells, lymphatic endothelial cell, hepatocyte, kidney cell, astrocyte, etc.
- • Immune cells : Macrophage, neutrophil, dendritic cell, monocyte, microglial cell, etc.
Liver
Liver
Liver
Liver
0 min
10 min
30 min
Real–time Intravital Imaging of Drug Delivery & Clearance in Metabolic & Digestive Organs
Drug delivery & clearance in metabolic organs
- • Target organs : Liver, kidney, lung, spleen, etc.
Liver
Liver
33 sec
294 sec
Drug infusion & absorption in digestive organs
- • Target organs : Small intestine, colon, etc.
Villi
Before
1 min
16 min
26 min
Mesentery
Before
1 min
19 min
26 min